Intrinsic pathway

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In molecular biology, the term intrinsic pathway may refer to multiple cascades of protein interactions.

  • The intrinsic pathway of apoptosis refers to cell death initiated by changes in mitochondria, also known as the mitochondrial pathway or intracellular pathway or intrinsic apoptosis.
  • The intrinsic pathway of blood coagulation is also known as the contact activation pathway and refers to a cascade of enzymatic reactions resulting in blood clotting.

Intrinsic Pathway Of “Clotting Cascade”

  • Stops bleeding within (internal) cut vessel
  • Foreign Substance (in contact with test


  • Factor XII (Hageman Factor)